Trastuzumab–Docetaxel Combination Chemotherapy Induced Severe Onychopathy
نویسندگان
چکیده
Sir, Taxanes, which are inhibitors of tubulin function in mitosis and used as cancer chemotherapy, are well known to be associated with onychopathy. Trastuzumab, a recombinant DNA‐derived humanized monoclonal antibody against the human epidermal growth factor receptor 2 protein (HER‐2) is used in combination with taxanes in advanced stage HER‐2 positive metastatic breast cancer.[1] We report the case of a 51‐year‐old post‐menopausal Indian lady with metastatic carcinoma of the left breast (Estrogen/Progesterone receptor negative; HER2/Neu positive) who developed severe taxane–trastuzumab‐induced onychopathy.
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